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. Author manuscript; available in PMC: 2016 Aug 21.
Published in final edited form as: ACS Chem Biol. 2015 Jun 12;10(8):1791–1796. doi: 10.1021/acschembio.5b00090

Table 1. MICs of (μg/ml) carbapenem antibiotics against A. baumannii ATCC 17978 producing various CHDLs.

Enzyme
Antibiotic Controla OXA-51 OXA-51Mb OXA-23c OXA-24c OXA-58c
Imipenem 0.125 2 16 32 64 8
Meropenem 0.25 8 64 64 128 4
Ertapenem 2 32 256 256 >256 32
Doripenem 0.125 8 64 32 128 4
a

Parental A. baumannii ATCC 17978 strain with the plasmid pNT221 without a β-lactamase gene.

b

OXA-51M denotes the OXA51 Trp222Met mutant enzyme.

c

The MICs of OXA-23, OXA-24 and OXA-58 for carbapenems have been previously reported.11