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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Ann Neurol. 2015 Jul 20;78(3):439–453. doi: 10.1002/ana.24454

Figure 6. Fibrillar plaque growth is observed in cognitively normal participants, but plateaus with clinical dementia.

Figure 6

A, The annualized change in PET PIB MCBP is compared by baseline PET PIB and CDR (n=38). Delta PET PIB is the annualized change in PET PIB MCBP at times closest to the SILK study. Reference red dotted line represents conditional cutoff for amyloid groups (0.18). CDR−/PET PIB− (circles), CDR−/PET PIB+ (squares), CDR+/PET PIB− (diamond), CDR+/PET PIB+ (triangles). B, C, Correlations between the annualized change in fibrillar amyloid by PET PIB and FTR Aβ42 indicate that increasing fibrillar amyloid deposition is positively correlated with increased FTR Aβ42. In Amyloid positive (triangles) participants, R=0.75, p=0.002, n=14 and in both Amyloid positive and Amyloid negative (circles) participants, R=0.56, p=0.0002, n=38. The color shows CDR sum of the boxes (redder signifies more impaired clinical dementia on a scale from 0–6).