Table 1.
Subject Demographics
| Sporadic AD (n=100) | Younger controls14 (n=12) | |
|---|---|---|
|
|
||
| Age (y) | 73.3 ± 6.6 (60.4 to 87.7) | 48.0 ± 14.6 (29.2 to 72.6) |
| Weight (kg) | 77.1 ±15.6 (42.2 to 122.5) | 89.0±20.8 (61.7 to 127.0) |
| BMI (kg/m2) | 26.6 ± 4.8 (16.5 to 40.3) | 29.3±6.3 (23.1 to 45.2) |
| Sex | 56M/44F | 5M/7 F |
| ApoE4 status | 58 without ApoE4/42 with ApoE4 | 8 without ApoE4/4 with ApoE4 |
| ApoE4 genotypes | E23 = 10 | E23 = 2 |
| E24 = 2 | E33 = 6 | |
| E33 = 48 | E34 = 4 | |
| E34 = 33 | ||
| E44 = 7 | ||
| PET PIB status | 37 with PET PIB score ≤ 0.18 | 12 with PET PIB score ≤ 0.18 |
| 25 with PET PIB score > 0.18 | ||
| 38 with no PET PIB score | ||
| PET PIB(−) group | PET PIB score = 0.042 ± 0.046 (−0.038 to 0.152) | |
| PET PIB(+) group | PET PIB score = 0.645 ± 0.281 (0.259 to 1.241) | |
| CSF AB42/40 status: | 49 with ratio ≥ 0.12 | |
| 51 with ratio < 0.12 | ||
| Amyloid status* | 51 without plaques | 12 without plaques |
| 49 with plaques | ||
| CDR-SB status | 44 with CDR-SB=0 | 12 with CDR-SB = 0 |
| 56 with CDR-SB>0 | ||
Values shown are mean ± StdDev (range)
*
Amyloid status: based on PET PIB score is available (subjects have plaques if PET PIB score > 0.18); based on CSF status if PET PIB score not available (CSF AB42/40 ratio < 0.12)