Table 1. Commonly deregulated genes in DLD-1 and MOLT-4 cells under microgravity.
| UPREGULATED GENES | |||
| GENE SYMBOL | GENE NAME | Log FC DLD-1 | Log FC MOLT-4 |
| ARRDC3 | arrestin domain containing 3 | 3.6286426 | 2.5424619 |
| ATF3 | activating transcription factor 3 | 2.6872826 | 1.0043197 |
| CCPG1 | cell cycle progression 1 | 1.5802538 | 1.8111625 |
| CDKN2AIP | CDKN2A interacting protein | 1.6052608 | 1.0670295 |
| CDKN2D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 1.3287859 | 1.0733795 |
| CREBBP | CREB binding protein | 1.6003945 | 1.1786065 |
| CREBRF | CREB3 regulatory factor | 1.7348738 | 1.2481394 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 1.6632779 | 1.1129959 |
| DDIT3 | DNA-damage-inducible transcript 3 | 2.0701203 | 1.280817 |
| EGR2 | early growth response 2 | 1.3966465 | 3.9244506 |
| ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 1.3279192 | 1.0439773 |
| ETV5 | ets variant 5 | 1.2021747 | 2.488372 |
| FGF7 | fibroblast growth factor 7 | 2.2669797 | 1.1106136 |
| GORAB | golgin, RAB6-interacting | 1.1204505 | 1.0041857 |
| HDAC9 | histone deacetylase 9 | 1.0828898 | 1.4470437 |
| HINT3 | histidine triad nucleotide binding protein 3 | 1.7376733 | 1.7083709 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 1.2518463 | 1.2009206 |
| IRS2 | insulin receptor substrate 2 | 2.5675535 | 1.0355048 |
| JUN | jun proto-oncogene | 2.8459454 | 3.4484391 |
| MIR1304 | microRNA 1304 | 1.694859 | 1.0175457 |
| NCOA7 | nuclear receptor coactivator 7 | 1.3721471 | 1.0397696 |
| NDFIP2 | Nedd4 family interacting protein 2 | 1.0812235 | 1.1697233 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 1.6272297 | 1.2976668 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) | 2.5150435 | 1.105514 |
| PTEN | phosphatase and tensin homolog | 1.2177935 | 1.0146773 |
| RAB30 | RAB30, member RAS oncogene family | 1.8227141 | 1.6890364 |
| SKIL | SKI-like oncogene | 1.7823422 | 1.4903564 |
| SMAD7 | SMAD family member 7 | 1.0359683 | 1.338062 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 1.2988296 | 1.3440051 |
| XIAP | X-linked inhibitor of apoptosis | 1.3545609 | 1.2860351 |
| ZFAND2A | zinc finger, AN1-type domain 2A | 1.9506464 | 1.2355728 |
| ZFY | zinc finger protein, Y-linked | 2.238248 | 1.2044845 |
| ZMYM5 | zinc finger, MYM-type 5 | 1.7800057 | 1.4686751 |
| DOWNREGULATED GENES | |||
| GENE SYMBOL | GENE NAME | Log FC DLD-1 | Log FC MOLT-4 |
| ASIC1 | acid-sensing (proton-gated) ion channel 1 | -1.1945584 | -1.4278164 |
| CD24 | CD24 molecule | -2.1321063 | -1.3863628 |
| CDCA7L | cell division cycle associated 7-like | -1.6832285 | -1.0647273 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -1.2500896 | -1.0963018 |
| DHFR | dihydrofolate reductase | -1.8050942 | -1.0276904 |
| DNHD1 | dynein heavy chain domain 1 | -1.464865 | -1.0485542 |
| DUT | deoxyuridine triphosphatase | -1.0620422 | -1.175415 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -1.0099685 | -1.0678835 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -1.0106502 | -1.0274181 |
| ENSA | endosulfine alpha | -1.0821726 | -1.1114485 |
| FANCL | Fanconi anemia, complementation group L | -1.2304835 | -1.0152798 |
| FAR1 | fatty acyl CoA reductase 1 | -1.0487332 | -1.0339952 |
| FGFR3 | fibroblast growth factor receptor 3 | -1.6760249 | -1.3410914 |
| GSPT1 | G1 to S phase transition 1 | -1.3995273 | -1.0519781 |
| GSTA4 | glutathione S-transferase alpha 4 | -1.1619577 | -1.0276983 |
| HES4 | hairy and enhancer of split 4 (Drosophila) | -1.1826415 | -2.0193136 |
| HMGB1 | high mobility group box 1 | -1.002748 | -1.2596858 |
| HMGB3 | high mobility group box 3 | -1.2634602 | -1.1885982 |
| HSPA4 | heat shock 70kDa protein 4 | -1.5835454 | -1.2644181 |
| IFI30 | interferon, gamma-inducible protein 30 | -1.5613956 | -1.5471194 |
| IFRD2 | interferon-related developmental regulator 2 | -1.1622665 | -1.0979714 |
| JPH1 | junctophilin 1 | -1.1266716 | -1.6309524 |
| LOC100653301 /// NRBP2 | nuclear receptor-binding protein 2-like /// nuclear receptor binding protein 2 | -1.5101182 | -1.0871661 |
| MTPAP | mitochondrial poly(A) polymerase | -2.2048273 | -1.046771 |
| NEURL1B | neuralized homolog 1B (Drosophila) | -1.2790649 | -1.0592682 |
| NFIA | nuclear factor I/A | -1.2247176 | -1.1426408 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -1.6084354 | -1.0683279 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | -1.4648097 | -1.3255553 |
| PLXNA1 | plexin A1 | -1.1962962 | -1.3295693 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -1.3692455 | -1.0695791 |
| POLR3H | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | -1.0398519 | -1.1780653 |
| RBBP4 | retinoblastoma binding protein 4 | -1.0829744 | -1.1924767 |
| TUBB | tubulin, beta class I | -1.1920624 | -1.0390439 |
Table shows a section of commonly deregulated genes under microgravity in both cell lines as revealed by microarray analysis. The complete list of genes is provided in S5 Table.