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. 2015 Aug 21;10(8):e0136242. doi: 10.1371/journal.pone.0136242

Fig 4. Effects of the stereoisomers of CCG-1423 and related compounds on MRTF-A/SRF-mediated transcriptional activity.

Fig 4

Promoter assay in NIH3T3 cells. Detailed procedures were described in Materials and Methods and the legend for Fig 3. For the last 24 h, cells were treated with vehicle or 0.3 μM of the indicated compound. The luciferase activity with vehicle only (cntl DMSO) was set at 100%. Each value represents the means ± SEMs of results from three independent experiments. Statistical differences were calculated using student’s t-test. Significance levels were as follows: CCG-1423 S vs CCG-1423 R, P = 0.01712; CCG-100602 S vs CCG-100602 R, P = 0.45219; CCG-203971 S vs CCG-203971 R, P = 0.45621.