Table 1. Selected properties of synthetic compounds.
compound | R-isomer | S-isomer | ||||
---|---|---|---|---|---|---|
[α]D (°) a) | rt (min) b) | ee (%) b) | [α]D (°) a) | rt (min) b) | ee (%) b) | |
CCG-1423 | +107 | 43.7 c) | >99.9 | –103 | 31.2 c) | >99.9 |
CCG-100602 | –78 | 8.8 d) | 98.8 | +79 | 5.4 d) | 99.0 |
CCG-203971 | –88 | 11.3 e) | 99.0 | +89 | 16.7 e) | 99.1 |
a) Measured in methanol; c 1; temperature: 27°C (CCG-1423), 25°C (CCG-100602 and CCG-203971).
b) Determined by HPLC, column: 4.6Φ × 250 mm; eluent: n-hexane/ethanol; flow rate: 1 ml/min; temperature: 30°C; detection: UV254 nm.
c) CHIRALPAK AD, n-hexane/ethanol = 200/3.
d) CHIRALPAK AD, n-hexane/ethanol = 85/15.
e) CHIRALPAK OD, n-hexane/ethanol = 85/15.