Table 1.

Association between sVEGF-C/D levels and clinicopathological feature of GBC

Parameters	Number	VEGF-C (pg/ml)a	p value	VEGF-D (pg/ml)b	p value
Age
< 63 years	15	8041.35 ± 1925.64	0.327	703.88 (548.00–1465.13)	0.220
≥ 63 years	16	7321.04 ± 2089.88		660.38 (446.50–1599.25)
Sex
Female	16	7318.29 ± 1970.20	0.324	644.06 (461.00–1149.75)	0.105
Male	15	8044.30 ± 2055.27		776.38 (446.50–1599.25)
Smoking status
Smoker	12	8060.85 ± 2277.43	0.399	754.63 (446.50–1599.25)	0.543
Non-smoker	19	7422.46 ± 1856.82		656.75 (461.00–1149.75)
Location
Neck	7	7863.53 ± 2196.52	0.336	671.25 (548.00–1465.13)	0.082
Body	3	6775.27 ± 734.17		569.75 (558.88–645.88)
Bottom	9	6884.40 ± 2161.90		602.38 (446.50–921.38)
Whole	12	8368.91 ± 1905.67		796.31 (508.13–1599.25)
Tumor size
< 4 cm	14	7797.32 ± 2166.12	0.754	627.75 (446.50–1465.13)	0.341
≥ 4 cm	17	7564.38 ± 1936.99		703.88 (508.13–1599.25)
Histological type
Adeno	17	7480.00 ± 2219.24	0.572	671.25 (446.50–1599.25)	0.451
Others	14	7899.79 ± 1782.19		696.63 (453.75–1465.13)
Histological grading
Poor	11	8360.97 ± 1974.50	0.378	703.88 (529.88–1465.13)	0.792
Moderate	15	7302.74 ± 1955.52		671.25 (453.75–1599.25)
Well	5	7249.04 ± 2278.15		689.38 (446.50–943.13)
Tumor depth
Tis-T2	10	6788.88 ± 1945.62	0.188	544.38 (446.50–758.25)	0.001*
T3	16	7906.59 ± 1756.33		799.94 (642.25–1465.13)
T4	5	8672.56 ± 2618.21		678.50 (548.00–1599.25)
LNM
N0	15	6807.64 ± 1663.66	0.011*	602.38 (453.78–823.50)	0.001*
N1	9	7725.51 ± 2142.83		751.00 (446.50–1149.75)
N2	7	9444.69 ± 1456.74		946.75 (678.50–1599.25)
Distant metastasis
M0	23	7177.17 ± 1767.94	0.018*	671.25 (446.50–1073.63)	0.047*
M1	8	9085.27 ± 2106.82		944.94 (548.00–1599.25)
Stage
0–II	9	7152.91 ± 1663.66	0.045*	558.88 (453.75–758.25)	0.002*
III	12	6993.21 ± 1958.07		727.44 (446.50–1073.63)
IV	10	8946.22 ± 1913.04		944.94 (548.00–1599.25)

^aPresented by mean ± standard deviation

^bPresented by median values and range

*p < 0.05