Table 3.

Results of COX’s univariate and multivariate analysis

Factors	Univariate analysis			Multivariate analysis
	Odd ratio	95 % CI	p value	Odd ratio	95 % CI	p value
Age	0.976	0.918–1.037	0.432
Sex (male/female)	0.531	0.182–1.548	0.246
Smoking Status (smoker/non-smoker)	0.463	0.161–0.337	0.155
Tumor location (neck/body/bottom/whole)	0.864	0.528–1.414	0.561
Tumor size (cm)	1.370	0.470–3.992	0.564
Histological type (adeno/others)	1.045	0.583–1.874	0.882
Histological grading (poor/moderate/well differentiation)	0.498	0.210–1.182	0.114
Tumor depth (Tis-T2/T3/T4)	4.203	1.837–9.616	0.001*	0.349	0.053–2.294	0.273
LNM (N0/N1/N2)	4.051	1.83–8.965	0.001*	0.277	0.044–1.725	0.169
Distant metastasis (M0/M1)	8.795	2.754–28.087	<0.001*	1.548	0.214–11.219	0.665
Stage (0–II/III/IV)	6.844	2.408–19.449	<0.001*	68.659	2.466–1191.634	0.013*
sVEGF-C (pg/ml)	0.122	0.027–0.551	0.006*	0.006	0–0.412	0.018*
sVEGF-D (pg/ml)	0.312	0.098–0.998	0.05*	2.171	0.38–12.413	0.384

*p < 0.05