Table 2.

QoL studies on LGG.

Reference	Study design/topic (number of patients)	Findings
Aaronson et al., 2011 [23]	Retrospective  case control  Cognitive deficits (195)	Epilepsy burden and neurocognitive deficits rather than time since diagnosis, tumor lateralization, extent of surgery, and radiotherapy show a consistent relationship with QoL
Yavas et al., 2012 [24]	Prospective cohort  Response to therapy (43)	Function scores return to baseline after active treatment in all patients but those who use antiepileptic drugs
Giovagnoli et al., 2014 [25]	Survey study  QoL and disease phase (291)	Affective well-being is predicted by the phase of disease, while self-perception and confidence are independent of tumor progression and treatment
Jakola et al., 2014 [26]	Retrospective cohort  QoL and surgery (79)	In long-term survivors an aggressive surgical approach does not lower QoL compared to watchful waiting
Nwachukwu et al., 2015 [27]	Retrospective cohort  Pediatric population (121)	Patients with tumor recurrence reported significantly lower role functioning, social functioning, and more financial problems compared to their counterparts