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. Author manuscript; available in PMC: 2015 Aug 23.
Published in final edited form as: Curr Opin Neurobiol. 2014 Apr 12;27:135–142. doi: 10.1016/j.conb.2014.03.007

Figure 1. A working model of the mechanisms that regulate the intrinsic regenerative ability of axon regeneration.

Figure 1

(1) To respond to axotomy, the neuronal cell bodies need to be informed by retrogradely transported injury signals. In addition to acute axotomy-induced changes such as ion influx, cytokines such as IL-6 and CNTF are up-regulated at the lesion site and/or around the cell body. As a result, DLK and Jak/STAT pathways are activated, resulting in the generation and transport of the injury signals. (2). How injured neurons respond to injury signals is dependent on their regenerative competence. An important determinant of the competence might be the mTOR activity but other molecular pathways likely exist.