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. Author manuscript; available in PMC: 2015 Aug 23.
Published in final edited form as: J Cell Biochem. 2015 Aug;116(8):1490–1499. doi: 10.1002/jcb.25103

Figure 2.

Figure 2

Domain map of the 11 human DNA glycosylases. The mature form of the most common isoform of each of these enzymes is shown as a grey rectangle. The number of amino acids displayed is based on these deposited sequences (Uniprot IDs: UNG1: P13051-2, TDG: Q13569, SMUG1: Q53HV7, AAG: P29372, MBD4: O95243, MUTYH: Q9UIF7, NTH1: P78549, OGG1-1a: O15527, NEIL1: Q96FI4, NEIL2: Q969S2, NEIL3: Q8TAT5). The number of putative N-terminal amino acids in the leader sequence that get cleaved upon mitochondrial localization were determined by MitoProt II [Claros and Vincens, 1996] and are indicated in an oval in this diagram. For NEIL2, there is no predicted N-terminal MTS thus far reported in the literature and thus it is indicated by “?”.