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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Dev Biol. 2015 Jul 2;405(1):108–122. doi: 10.1016/j.ydbio.2015.07.001

Figure 7.

Figure 7

Mechanism of folate and retinoic acid signaling interaction. A–B) Representative transverse sections through the face labeled with cleaved caspase-3 (green) and counterstained with propidium iodide. This was consistent in at least 10 embryos at equivalent locations in the face All images were taken at the same magnification, scale bar=175μm. D) Model of how folinic acid supplementation prevents median orofacial clefts. E) Model of the mechanism by which RAR and DHFR inhibition could synergize.