Table 4.
The distribution of 9q21 haplotypes among cases and controls.
| Number | rs4077632 | rs2807303 | rs2777781 | rs11139451 | rs12237222 | rs12551710 | Frequencies | P value | OR (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|---|
| Controls | POP | |||||||||
| Six SNP-haplotype associations with response | ||||||||||
| 1 | A | T | A | T | T | C | 0.1334 | 0.0985 | — | 1.00 |
| 2 | A | C | A | T | T | C | 0.1185 | 0.0943 | 0.38 | 0.59 (0.19–1.90) |
| 3 | G | C | A | T | G | C | 0.0436 | 0.0937 | 0.24 | 1.92 (0.65–5.71) |
| 4 | A | C | A | T | G | C | 0.059 | 0.1019 | 0.029 | 3.36 (1.13–9.95) |
|
| ||||||||||
| Five SNP-haplotype associations with response | ||||||||||
| 1 | A | C | A | T | — | C | 0.1807 | 0.205 | — | 1.00 |
| 2 | A | T | A | T | — | C | 0.1662 | 0.1324 | 0.96 | 1.02 (0.48–2.16) |
| 3 | G | C | A | T | — | C | 0.1146 | 0.1171 | 0.68 | 0.85 (0.39–1.86) |
| 4 | A | C | T | T | — | C | 0.0949 | 0.0763 | 0.63 | 0.81 (0.34–1.92) |
|
| ||||||||||
| Two SNP-haplotype associations with response | ||||||||||
| 1 | — | — | A | — | T | — | 0.4581 | 0.3663 | — | 1.00 |
| 2 | — | — | A | — | G | — | 0.2782 | 0.3575 | 0.0091 | 1.72 (1.15–2.59) |
| 3 | — | — | T | — | T | — | 0.1328 | 0.167 | 0.064 | 1.62 (0.97–2.70) |
| 4 | — | — | T | — | G | — | 0.1309 | 0.1092 | 0.63 | 0.88 (0.53–1.47) |
Only haplotypes with total frequencies ≥10% are considered. Analysis is adjusted by age, body mass index (BMI), peritoneal trauma in childbirth, and vaginal parity. Significant results are in bold.