Table 2.
The effect of PEP on FBG levels in DM rats.
| Group | FBG (mg/dL) | ||||
|---|---|---|---|---|---|
| Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | |
| Control | 155.34 ± 35.1∗ | 176.76 ± 38.52∗ | 161.64 ± 27.18∗ | 161.10 ± 29.88∗# | 138.78 ± 28.62∗ |
| Model | 321.48 ± 46.1# | 258.48 ± 35.82# | 248.76 ± 39.60# | 283.68 ± 37.98# | 258.12 ± 58.68# |
| Metformin HC | 328.86 ± 14.58∗ | 148.32 ± 15.66∗ | 151.38 ± 16.38∗# | 153.18 ± 16.38∗# | 150.48 ± 19.08∗#& |
| 150 mg/kg PEP | 297.36 ± 40.86# | 180.72 ± 19.62∗ | 167.76 ± 41.40∗ | 194.76 ± 34.02∗# | 162.00 ± 33.30∗#& |
| 300 mg/kg PEP | 291.42 ± 36.54# | 159.48 ± 28.26∗ | 152.28 ± 36.90∗ | 172.08 ± 38.88∗ | 149.04 ± 34.56∗& |
| 600 mg/kg PEP | 325.08 ± 44.64# | 175.14 ± 26.10∗ | 160.74 ± 29.16∗ | 173.34 ± 31.32∗ | 158.76 ± 37.80∗& |
A DM model was established by feeding rats a high-fat diet and injecting them with a low dose of STZ. After the model was established, PEP (150, 300, and 600 mg/kg) was administered intragastrically for 28 d. Blood samples from the caudal vein were collected to determine FBG levels using a blood glucose meter. The data are presented as the mean ± standard deviation (n = 10 rats). Compared with the model group: ∗ P < 0.05; compared with the control group: # P < 0.05; compared with day 0: & P < 0.05.