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. 2015 Aug 24;9:309. doi: 10.3389/fncel.2015.00309

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Copyright © 2015 Scharinger, Eckrich, Vandael, Schönig, Koschak, Hecker, Kaur, Lee, Sah, Bartsch, Benedetti, Lieb, Schick, Singewald, Sinnegger-Brauns, Carbone, Engel and Striessnig.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hearing function in Cav1.3DCRD^HA/HA mice. (A) ABR thresholds (mean ± SD) of Cav1.3DCRD^HA/HA mice were normal for click stimuli (WT and Cav1.3DCRD^HA/HA: n = 8/16 animals/ears) and as a function of stimulus tone frequency (WT: n = 6/12 animals/ears and Cav1.3DCRD^HA/HA: n = 7/13 animals/ears). Thresholds could be measured in (n = animals/ears, frequency in kHz): WT: 2/3, 2; 6/9, 2.8; 6/12, from 4 to 22.6; 3/6, 32; 3/6, 45.2; Cav1.3DCRD^HA/HA: 2/3, 2; 7/13, from 2.8 to 32; 4/8, 45.2. (B) Mean DPOAE maximum amplitudes (signal to noise ratio) ± SD at f1 = 9.1 kHz, L1 = 55 dB SPL, f2 averaged over 10–18 kHz, and L2 = 45 dB SPL were normal in Cav1.3DCRD^HA/HA (n = 7/14 animals/ears) compared with WT mice (n = 7/14 animals/ears, p = 0.12), indicating normal function of the cochlear amplifier.