Fig. 9.

LDH activity, but not lactate, seems to regulate SUR2A levels. A–B. Original Western blots with SUR2A antibody applied on extracts from H9c2 cells in the absence (control) and presence of galloflavin (A) or sodium oxamate (B) and corresponding graphs. Each bar is a mean ± SEM (n = 3). C–E. Graphs showing levels of lactate (C), LDH (D) and SUR2A (E) and in untreated cells and cells treated with sodium lactate (30 mM). Each bar is a mean ± SEM (n = 3). F. A graph showing cell survival in H9c2 cells infected by luciferase (control cells labelled as M-LDH) and cell infected by 193gly-M-LDH. Each bar is a mean ± SEM (n = 3–5). *P < 0.05. AU = arbitrary units.