Figure 5. Examples of chromatin-modified loci unlinked to changes in gene expression.
(A) pyr is actively transcribed, and not significantly repressed by Hairy, (B) while nht is not expressed at this stage. ChIP-seq tracks for H4Ac, H3K27Ac, H3K4me1 and H3K4m3 are shown before (−) and after Hairy (+) induction.
Figure 5—figure supplement 1. Global association of Hairy binding with histone mark alterations.
Changes in histone marks, predominantly reductions, were detected for more than half of the Hairy bound genes. Genes were divided into two groups; no detectable histone mark changes vs at least one change, and then ranked (right to left) by height of Hairy peaks and total number of changes in histone marks. Differential changed regions of histone marks and Hairy peaks were assigned to genes with the closest TSS.