Table 1.
Incidence, prevelance and other statistics for five cardiomyopathies and a more prevalent pediatric congential heart disease called Tetralogy of Fallot or ToF, with associated right ventricular abnormalities.
| CM Subtypes | HCM | DCM | ARVC/D | NCM | RCM & Iron mediated CM | ToF16 |
|---|---|---|---|---|---|---|
| Incidence (I) OR Prevalence (P) | P = 1:500 in absence of aortic valve disease or systemic hypertension | I = 5-8 cases /100,000 P = 36 cases /100,000 |
I = 1/ 10,000 | I = 0.05% to 0.24% | I = 11.4% to 15.1% in Thalassemia major patients Transfusion Dependent |
I = 9/1000 live births |
| #Patients evaluated for CM | 46 | 129 | 44 | 31 | 35 | 684 |
| Total number of positive diagnosis w/ CMRI CM | 11 | 18 | 4 | 15 | 12 | 119 |
| cMRI-based QUANTITATIVE markers | ||||||
| LV myocardial wall thickness | ABNL | ABNL | NL | ABNL | ABNL | NL |
| LV mass index | ABNL | ABNL | NL | ABNL | ABNL | NL |
| LV Volume index | ABNL | ABNL | NL | ABNL | ABNL | ABNL |
| RV Volume index | NL | ABNL | ABNL | NL | ABNL | ABNL |
| cMRI-based QUALITATIVE markers | ||||||
| Myocardial Delayed Enhancement | +/- | +/- | +/- | +/- | +/- | + |
| Wall motion abnormalities | +/- | +/- | +/- | +/- | +/- | +/- |
Some examples of standard quantitative and qualitative markers from cMRI that are associated with observed normal (NL) or abnormal (ABNL) values in each disease based on patients seen at the Children's Hospital of Pittsburgh (CHP) between 2000 and 2013. LV refers to Left Ventricular and RV to Right Ventricular regions. The qualitative variables shown in the table are assigned values of + or - indicating that some patients for the particular subtype indicated presence or absence of that abnormality.