Figure 2.

(A) Simulated rate dependence of H₂O₂-induced EADs. The EAD incidence rate is predicted to be higher at low pacing rates (long PCLs) in the presence of 200 μM H₂O₂. (B) PCL dependence of APD under control (CTRL) conditions (solid circles) and in the absence of baseline I_NaL (open circles). Under control conditions, the APD increases with PCL and this rate-dependent increase is abolished in the absence of I_NaL. (C) Simulated APs from a 6 s PCL protocol in the absence of oxidative stress (CTRL, 0 μM H₂O₂) (12,500 Ca²⁺ release units). Results for the last six consecutive APs are shown. (D) Simulated APs, all of which exhibit EADs, under conditions of elevated oxidative stress (200 μM H₂O₂). To see this figure in color, go online.