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Simulated rate dependence of CaMKII-mediated effects on ICaL, JRyR, and INaL in the absence (CTRL, black) or presence (blue) of H2O2. EADs are indicated with solid blue bars. Simulated PCL dependence of (A) the maximum fraction of open LCCs gating in mode 2, (B) the diastolic RyR flux (JRyR), and (C) INaL (average value calculated from 100 to 300 ms) in the absence (CTRL) or presence of oxidative stress. To see this figure in color, go online.
