Figure 6.

Effects of NCX and RyR inhibition on H₂O₂-induced EADs. (A) Simulated APs from a 6 s PCL protocol in the presence of oxidative stress (ROS) including the presence of either NCX inhibitor (ROS + NCX block) or RyR inhibitor (ROS + RyR block). Note that no EADs occur in the ROS + NCX block condition, whereas they are present in the ROS + RyR block condition. Whole-cell NCX current (I_NCX), as well as RyR flux (J_RyR), before and after block are shown in Figs. S10 A and S13 A. (B) Box plots of diastolic [Ca²⁺]_i, systolic [Ca²⁺]_i, and NCX RP under ROS, ROS + NCX block, and ROS + RyR block conditions. (C) Box plots of APD, absolute TTRP, and TTRP/APD (i.e., normalized TTRP) under the same conditions. To see this figure in color, go online.