Figure 4.

Atomic structure of an amyloid fibre formed from APP. The structure (PDB 2yti) has been mapped with the UniProt "polypeptide region" feature lane, which indicates the location of enzymatic cleavage sites. If the indicated cleavages by gamma secretase (at residue 711) or alpha secretase (at residues 687-688) occur, the APP amyloid fibre could not form. Thus, this figure shows the power of combining features with structures, as it suggests potential research directions that could be pursued as potential treatments for Alzheimer's.