Fig. S5.

Paclitaxel inhibits phosphorylation of ERK and FoxO3, which is reversed by inhibition of glutathione synthesis. MDA-MB-231 subclones (NTC, HIF-1α, xCT, or GCLM knockdown) were treated without or with 10 nM paclitaxel for 72 h, and immunoblot assays were performed.