Fig. S4.

Female mice with humanized SNP alleles are normally fertile. (A) Litter sizes of humanized models. The WT data are pooled from littermates combined from the different mutant alleles. (B) Quantification of ovarian follicle types (± SD). “Other follicles” consist of primary, secondary, preantral, and antral follicles. (C and D) The Cdk2^Y15S allele does not impact ovarian histology. Shown are H&E-stained paraffin sections of 3-wk-old mouse ovaries. Arrowheads indicate a primordial follicle, and the arrow indicates a secondary follicle. A preantral follicle from each section is also labeled. ns, not significant; wk, week. (Scale bar: 100 μm.)