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. 2015 Aug 3;112(33):10407–10412. doi: 10.1073/pnas.1505675112

Fig. S4.

Fig. S4.

Wound closure in aging K14S mice. (A) Average wound size (mean ± SEM) after injury by an 8-mm dermal punch biopsy in 11-mo-old K14S mice, treated with veh or TAM (veh, n = 13; TAM, n = 11) at age 4 mo. Percent wound size refers to the wound area relative to the initial wound area × 100. (B) Representative photomicrographs of H&E staining of skin of K14S mice at 4, 7, and 10 mo after veh (Left) or TAM (Right) treatment (veh and TAM, n = 5). (C and D) Heat map (C) and mRNA levels (D) of genes expressed predominantly in basal interfollicular epidermis (IFE), suprabasal IFE, K14+ stem cells, and involucrin (Ivl) committed progenitor cells, analyzed by qPCR, in skin from K14S mice at 4 mo and 11–20 mo after treatment with veh or TAM.