Fig. 4.

Observed per base de novo substitution rate per gene vs. sequenced exonic length (bp) per gene. Red diamonds, genes that were successfully sequenced for more than 80% of exon region; black square, mean substitution density within a 500-bp window; black line, mean substitution density $\langle \mu \rangle =$ 2.0$\times$ 10⁻⁴/bp; blue error bars, 95% CI determined by binomial distribution (SI Text); black diamonds with red center, calls for hypermutated genes.