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Effect of S protein mutants on antibody binding
| Mutation | LCA60 | LCA57 |
| V33A | + | +/− |
| E536A | +/− | + |
| H486A | + | + |
| T489A | — | + |
| K493E | — | + |
| K496E | + | + |
| T512A | + | + |
| Y540A | + | + |
| Y540C | + | + |
| Y541A | + | + |
| R542E | + | + |
| K543E | + | + |
| P547S | + | + |
| E565A | — | + |
Mutations of the residues indicated in each row either affected (–), did not affect (+), or marginally affected (+/−) binding of either antibody LCA60 or LCA57.
