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Biosynthesis of thienamycin and activity of ThnK. Two enzymes, ThnE and ThnM, form the (3S,5S)-carbapenam 2, which is then acted on by other enzymes, likely including ThnK, ThnL, and ThnP, to form thienamycin. Correspondingly, CarB and CarA can also form 2, which CarC can convert to the simple carbapenem 3. The demonstrated activity of ThnK is highlighted in gray.
