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Carbapenam synthetic library and detection and quantification of SAM-derived products of ThnK. (A) Compounds synthesized to probe ThnK activity. (B) LC-MS/MS detection of enzymatic SAM-derived coproducts SAH (385.4→136 m/z) and 5′-dA (252.1→136 m/z). The EICs for the transitions of SAH and 5′-dA are shown for each reaction. The reaction with compound 11 yielded the highest levels of these SAM-derived coproducts. Quantified levels of SAH and 5′-dA are shown for each reaction.
