Supplementary Figure 1.

Activation of JAK/STAT3 pathway in serial sections. Red arrowheads indicate boundary of dysplastic foci. (A) Dysplasia with large cell changes. PCNA expression correlated with pStat3 expression. Inflammatory genes activated by JAK/STAT3 pathway are also expressed. (B) Dysplasia with inflammatory changes. Enhanced proliferation measured by PCNA expression precisely correlates with pStat3 expression. Downstream genes are also activated.