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. 2015 Aug 18;17(7):598–611. doi: 10.1016/j.neo.2015.07.006

Figure 1.

Figure 1

Figure 1

Wnt-signaling target genes expression in Barrett’s metaplasia: (A-D) Box plots of qRT-PCR data for mRNA expression of the Wnt target genes AXIN2, Dkk1, Cyclin D1, and c-MYC in squamous esophageal mucosa (SQ) and metaplastic mucosa (BE) of healthy individuals (n = 10) and Barrett’s patients (n = 15) (normalized with β-actin). Box plots of (E) Wnt3a and (F) CDX2 mRNA expression in the same samples as described above. (G) Immunohistochemistry for AXIN2, Dkk1, c-Myc, and Cyclin D1 protein expression in Barrett’s metaplasia as opposed to squamous mucosa (Supplementary Figure 1). (P values are provided, Mann-Whitney test).

Wnt-signaling target genes expression in Barrett’s metaplasia: (A-D) Box plots of qRT-PCR data for mRNA expression of the Wnt target genes AXIN2, Dkk1, Cyclin D1, and c-MYC in squamous esophageal mucosa (SQ) and metaplastic mucosa (BE) of healthy individuals (n = 10) and Barrett’s patients (n = 15) (normalized with β-actin). Box plots of (E) Wnt3a and (F) CDX2 mRNA expression in the same samples as described above. (G) Immunohistochemistry for AXIN2, Dkk1, c-Myc, and Cyclin D1 protein expression in Barrett’s metaplasia as opposed to squamous mucosa (Supplementary Figure 1). (P values are provided, Mann-Whitney test).