Table 2.

Brain regions where BMI predicts diffusion measures in a VBM whole brain analysis, controlling for age, hypertension, and diabetes status.

	MNI					Cluster size
	Lobe	x	y	z	tvalue
FA decrease with BMI increase
R cst/cbt	BS	8	−14	−16	4.96	45
AD decrease with BMI increase
R genu, arc, unc, alic	F	8	32	8	4.79	823
L genu, arc	F	−14	40	0	4.39	273
R frontal wm	F	30	18	32	3.25	12
R alic	SC	12	12	−8	3.63	46
L alic	SC	16	10	6	3.63	24
L alic	SC	−16	10	4	3.61	33
R scr	F	16	0	60	3.89	16
R scr	F	10	−28	56	3.51	65
L scr	F	−10	−30	52	3.14	13
R scr	P	20	−66	38	3.38	17
R scr	P	22	−44	52	4.17	59
L scr	P	−20	−50	48	3.35	36
L slf	T	−38	−44	10	4.12	70
R occipital wm	O	20	−84	18	3.66	19
L occipital wm	O	−24	−88	−2	3.56	55
R scp/icp	CB	6	−62	−32	4.97	69
L scp/icp/mcp	CB	−8	−62	−32	4.65	191

The coordinates of the location of maximal significance (from Montreal Neurological Institute template [MNI]), the t value, and cluster size (voxel number) of each cluster are provided. arc: arcuate fasciculus, alic: anterior limb of the internal capsule, AD: axial diffusion, BS: brain stem, CB: cerebellum, cbt: cortico bulbar tract, cst: corticospinal tract, F: frontal, FA: fractional anisotropy, icp: inferior cerebellar peduncle, L: left hemisphere, mcp: middle cerebellar peduncle, O: occipital, R: right, P: parietal, scp: superior cerebellar peduncle, scr: superior corona radiata, slf: superior longitudinal fasciculus, T: temporal, unc: uncinate fasciculus.