Table 3.
Rates of cancer per 1000 mammograms by tumor characteristics, mode of detection, and imaging modality, Breast Cancer Surveillance Consortium 2003–2011
| Cancer Characteristic | Screen-Detected Cancer (n=13,418) | Interval Cancer (n=2,311) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Digital | Film | Digital | Film | |||||||||
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|
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| N cancers | Column % | Rate per 1000 | N cancers | Column % | Rate per 1000 | N cancers | Column % | Rate per 1000 | N cancers | Column % | Rate per 1000 | |
|
|
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| Total | 5,441 | (86%) | 4.47 | 7,977 | (85%) | 4.42 | 895 | (14%) | 0.73 | 1416 | (15%) | 0.79 |
| DCIS | 1,638 | (30%) | 1.34 | 1,854 | (23%) | 1.03 | 106 | (12%) | 0.09 | 132 | (9%) | 0.07 |
| Invasive | 3,803 | (70%) | 3.12 | 6,123 | (77%) | 3.40 | 789 | (88%) | 0.65 | 1,284 | (91%) | 0.71 |
| For invasive cancers: | ||||||||||||
| AJCC Stage | ||||||||||||
| I | 2,313 | (63%) | 1.90 | 3,530 | (61%) | 1.96 | 311 | (41%) | 0.26 | 466 | (39%) | 0.26 |
| IIA | 780 | (21%) | 0.64 | 1,200 | (21%) | 0.67 | 229 | (30%) | 0.19 | 338 | (28%) | 0.19 |
| IIB | 334 | (9%) | 0.27 | 552 | (10%) | 0.31 | 103 | (14%) | 0.08 | 162 | (13%) | 0.09 |
| III | 211 | (6%) | 0.17 | 393 | (7%) | 0.22 | 97 | (13%) | 0.08 | 187 | (16%) | 0.10 |
| IV | 34 | (1%) | 0.03 | 67 | (1%) | 0.04 | 21 | (3%) | 0.02 | 48 | (4%) | 0.03 |
| Unknown | 131 | (3%) | 0.11 | 381 | (6%) | 0.21 | 28 | (4%) | 0.02 | 83 | (6%) | 0.05 |
| SEER summary stage | ||||||||||||
| Local | 2,868 | (78%) | 2.35 | 4,433 | (76%) | 2.46 | 492 | (64%) | 0.40 | 723 | (59%) | 0.40 |
| Regional | 776 | (21%) | 0.64 | 1,362 | (23%) | 0.76 | 252 | (33%) | 0.21 | 459 | (37%) | 0.25 |
| Distant | 36 | (1%) | 0.03 | 68 | (1%) | 0.04 | 23 | (3%) | 0.02 | 49 | (4%) | 0.03 |
| Unknown | 123 | (3%) | 0.10 | 260 | (4%) | 0.14 | 22 | (3%) | 0.02 | 53 | (4%) | 0.03 |
| Tumor size | ||||||||||||
| <=10 mm | 1,184 | (34%) | 0.97 | 1,778 | (32%) | 0.99 | 124 | (17%) | 0.10 | 193 | (16%) | 0.11 |
| 11–20 mm | 1,410 | (40%) | 1.16 | 2,266 | (41%) | 1.26 | 269 | (36%) | 0.22 | 431 | (37%) | 0.24 |
| >20 mm | 903 | (26%) | 0.74 | 1,536 | (28%) | 0.85 | 346 | (47%) | 0.28 | 548 | (47%) | 0.30 |
| Unknown | 306 | (8%) | 0.25 | 543 | (9%) | 0.30 | 50 | (6%) | 0.04 | 112 | (9%) | 0.06 |
| Nodal status | ||||||||||||
| Negative | 2,917 | (78%) | 2.39 | 4,534 | (76%) | 2.51 | 504 | (65%) | 0.41 | 757 | (61%) | 0.42 |
| Positive | 812 | (22%) | 0.67 | 1,425 | (24%) | 0.79 | 270 | (35%) | 0.22 | 493 | (39%) | 0.27 |
| Unknown | 74 | (2%) | 0.06 | 164 | (3%) | 0.09 | 15 | (2%) | 0.01 | 34 | (3%) | 0.02 |
| Grade | ||||||||||||
| I | 1142 | (32%) | 0.94 | 1,635 | (29%) | 0.91 | 153 | (21%) | 0.13 | 235 | (21%) | 0.13 |
| II | 1597 | (45%) | 1.31 | 2,436 | (44%) | 1.35 | 313 | (43%) | 0.26 | 455 | (40%) | 0.25 |
| III | 838 | (23%) | 0.69 | 1,512 | (27%) | 0.84 | 269 | (37%) | 0.22 | 447 | (39%) | 0.25 |
| Unknown | 226 | (6%) | 0.19 | 540 | (9%) | 0.30 | 54 | (7%) | 0.04 | 147 | (11%) | 0.08 |
| Estrogen receptor status | ||||||||||||
| Positive | 3137 | (87%) | 2.57 | 4,630 | (85%) | 2.57 | 589 | (79%) | 0.48 | 836 | (74%) | 0.46 |
| Negative | 468 | (13%) | 0.38 | 807 | (15%) | 0.45 | 161 | (21%) | 0.13 | 294 | (26%) | 0.16 |
| Unknown | 198 | (5%) | 0.16 | 686 | (11%) | 0.38 | 39 | (5%) | 0.03 | 154 | (12%) | 0.09 |
| Progesterone receptor status | ||||||||||||
| Positive | 2798 | (78%) | 2.30 | 4022 | (75%) | 2.23 | 521 | (70%) | 0.43 | 733 | (65%) | 0.41 |
| Negative | 804 | (22%) | 0.66 | 1,373 | (25%) | 0.76 | 227 | (30%) | 0.19 | 393 | (35%) | 0.22 |
| Unknown | 201 | (5%) | 0.16 | 728 | (12%) | 0.40 | 41 | (5%) | 0.03 | 158 | (12%) | 0.09 |
| HER2 | ||||||||||||
| Positive | 316 | (12%) | 0.26 | 549 | (15%) | 0.30 | 76 | (14%) | 0.06 | 125 | (18%) | 0.07 |
| Negative | 2243 | (88%) | 1.84 | 2,995 | (85%) | 1.66 | 478 | (86%) | 0.39 | 574 | (82%) | 0.32 |
| Unknown | 1,244 | (33%) | 1.02 | 2,579 | (42%) | 1.43 | 235 | (30%) | 0.19 | 585 | (46%) | 0.32 |
| Triple Negative | ||||||||||||
| Yes | 210 | (8%) | 0.17 | 287 | (8%) | 0.17 | 78 | (14%) | 0.06 | 103 | (15%) | 0.06 |
| No | 2333 | (92%) | 1.91 | 3148 | (92%) | 1.91 | 473 | (86%) | 0.39 | 578 | (85%) | 0.32 |
| Unknown | 1,260 | (33%) | 1.03 | 2,688 | (44%) | 1.03 | 238 | (30%) | 0.20 | 603 | (47%) | 0.33 |