Soemantri 1997.
Methods | Randomised controlled trial. 2‐arm design with individual randomisation. | |
Participants | 97 children, both sexes (sex distribution not reported), aged 7‐11 years, attending the primary school Batang, in Indonesia. Inclusion criteria: anaemia (Hb below 120 g/L); not taking iron supplements during the last six months; no evidence of hepatosplenomegaly, haemoglobinopathy, acute or chronic disease, severe anaemia. Baseline prevalence of anaemia: 67.36%. Socioeconomic status not reported. | |
Interventions | Children were divided into 2 groups and randomly assigned Group 1 (n = 52): children received daily 3 mg of iron per kilogram (as ferrous sulphate); Group 2 (n = 45): children received once a week 3 mg of elemental iron per kilogram (as ferrous sulphate) (approximately 85 mg of iron per week). Length of the intervention: 3 months. |
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Outcomes | Anthropometric measurements (weight for age Z‐score, height for age Z‐score) and haemoglobin. | |
Notes | The solutions were given by the school teachers on school days with careful supervision. All children with intestinal parasites were treated prior to supplementation. Z‐scores used the National Center for Health Statistics data as a reference. Malaria endemicity not reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Children were randomly assigned to the study groups. Method of sequence generation not described. |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding (performance bias and detection bias) All outcomes | High risk | Participants: not reported. Personnel: not reported. Outcome assessors: not reported. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Two children (3.8%) were excluded from the daily group because of gastrointestinal side effects. |
Selective reporting (reporting bias) | Unclear risk | There is insufficient information to permit judgement. |
Other bias | Low risk | The study appears to be free of other sources of bias. |