Table 1.
Characterization of the prepared SH-ASA/Cur nanoparticles
| Sample | Solvent | Drug: polymera | EEA (%) | EEC (%) | Size (nm) | PDI | DLA (%) | DLC (%) | Stability |
|---|---|---|---|---|---|---|---|---|---|
| S1 | Chloroform | 1:20 | 80±3.12 | 92.76±4.56 | 387.6±31.3 | 0.418±0.047 | 3.09±0.08 | 0.93±0.01 | 2 hours |
| S2 | Dichloromethane | 1:20 | 92.65±4.26 | 90.84±4.23 | 284±18.6 | 0.286±0.028 | 3.51±0.06 | 0.90±0.02 | 24 hours |
| S3 | Ethyl acetate | 1:20 | 83.17±3.04 | 87.3±3.68 | 122.3±6.8 | 0.179±0.016 | 3.15±0.05 | 0.88±0.05 | 72 hours |
| S4 | Ethyl acetate | 1:5 | 35.06±2.76 | 40.74±2.45 | 271.6±13.6 | 0.402±0.02 | 5.12±0.13 | 1.65±0.11 | <10 minutes |
| S5 | Ethyl acetate | 1:10 | 70.82±4.43 | 79.71±5.88 | 172.2±8.8 | 0.276±0.012 | 5.38±0.14 | 1.53±0.09 | 4 hours |
| S7 | Ethyl acetate | 1:30 | 89.56±3.56 | 94.12±3.14 | 107.1±2.3 | 0.171±0.016 | 2.21±0.05 | 0.74±0.02 | >96 hours |
Notes:
a
In feed; Data is presented as mean ± standard deviation.
Abbreviations: SH-ASA, SH-aspirin; Cur, curcumin; EEA, entrapment efficiency of aspirin; EEC, entrapment efficiency of curcumin; PDI, polydispersity index; DLA, drug-loading efficiency of aspirin; DLC, drug-loading efficiency of curcumin.