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. Author manuscript; available in PMC: 2016 Mar 19.
Published in final edited form as: Nature. 2015 Mar 11;519(7543):315–320. doi: 10.1038/nature14227

Figure 3. Mutate-and-CS fingerprinting ES1 and ES2.

Figure 3

a, Multi-state equilibrium between WB and WC-like dG•dT mispairs. ES1/ES2 populations and weights are shown (25 °C and pH 6.9). pES2 estimated based on the observed apparent pKa. b, CS fingerprinting dG•dT ES1/ES2 using chemical modifications and structure-based DFT predictions of CSs. ES1 DFT CSs are given for 80:20 dGenol•dT:dG•dTenol weighting. c, m6dG•dT structure12,30. d, dG•5BrdU– ES2 stabilized relative to dG•dT– ES2. Populations and weights (10 °C and pH 6.9) are shown.