Fig 6. Predicted naphthenic acid degradation pathway in CR3.

(A) Peripheral ring-cleavage pathway; (B) Central oxidative degradation pathways; (C) The structure of compound A. Compounds in red are substrates. Enzyme genes are marked on the right of arrows, including gene description (purple color), gene symbol (green color) and gene identifications (light blue color). If CR3 genome only encoded isoenzyme gene, gene identifications were marked in italic. Isoenzyme gene were defined as a gene assigned to a same enzyme class with the same EC NO. And enzyme genes with unknown gene symbol were marked as ‘?’.