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. 2015 Aug 24;10(8):e0136155. doi: 10.1371/journal.pone.0136155

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© 2015 Botting et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — H1975 cells were plated at 3000 cells per well in a 96 well plate and after 24 hours were treated with varying combinations of EGFR inhibitor erlotinib and c-Met inhibitor SU11274. After 72 hours of drug exposure MTT cell viability assay was performed. Synergistic inhibitory effects on H1975 cell growth inhibition were observed following combination treatment of erlotinib and SU11274 at concentrations of 1 μM and 3 μM (1:1 ratio of each drug). Drug synergism was calculated using Calcusyn v2.0 software and the CI values were below 1. ANOVA analysis was used to determine statistically significant differences between treatments (n = 3, p<0.01).