Table 1. Subject characteristics of the patients in AIs-related MS-AEs group and controls.

Characteristic	Cases (n = 208)		Controls (n = 212)
	n	%	n	%	p value
Age (years)					0.769
≥58	102	49.0	107	50.5
<58	106	51.0	105	49.5
Mean ± SD	57.3 ±15.7		58.1 ±14.9		0.091
Treatment arm					0.783
Anastrozole	68	32.7	72	34.0
Letrozole	140	67.3	140	66.0
Median treatment time (months)	24.9± 7.6		25.3± 8.2		0.145
ER/PR status					0.653
ER+/PR+	133	63.9	140	66.0
ER+/PR–	58	27.9	60	28.3
ER–/PR+	17	8.2	12	5.7
Her-2 status					0.978
Negative	142	68.3	145	68.4
Positive	66	31.7	67	31.6
Histological grade					0.846
I	30	14.4	32	15.1
II	146	70.2	147	69.3
III	32	15.4	33	15.6
Years since menopause					0.698
≥10	65	31.2	70	33.0
<10	143	68.8	142	67.0
Median BMI (kgm -2 , range)					0.773
≥25	105	50.5	110	51.9
<25	103	49.5	102	48.1
Prior chemotherapy					0.580
No	66	31.7	62	29.2
Yes	142	68.3	150	70.8
Prior taxane treatment					0.145
No	120	65.5	137	68.2
Yes	88	34.5	75	31.8
Prior tamoxifen treatment					0.591
No	172	82.7	171	80.7
Yes	36	17.3	41	19.3
Prior radiation therapy					0.894
No	67	32.2	67	31.6
Yes	141	67.8	145	68.4
Smoking					0.781
No	190	91.3	192	90.6
Yes	18	8.7	20	9.4

Note: SD = standard deviation; BMI = body mass index.