Table 3. Association between risk of AI-related musculoskeletal adverse events and 29 SNPs of RANK, RANKL and OPG.

			Minor Allele Frequency
dbSNP	Gene	Chr	Position	Location	cases	controls	OR	95%CI	P value
rs12457042	RANK	18	58144433	intron	0.151	0.146	1.042	0.713–1.524	0.847
rs4941129	RANK	18	58151457	intron	0.409	0.413	0.983	0.747–1.294	0.944
rs7237982	RANK	18	58155233	Intron	0.065	0.061	1.062	0.609–1.853	0.888
rs7239261	RANK	18	58156026	Intron	0.216	0.203	1.085	0.778–1.513	0.672
rs12969154*	RANK	18	58157123	Intron	0.324	0.330	0.971	0.727–1.296	0.883
rs4369774	RANK	18	58161428	Intron	0.315	0.311	1.017	0.760–1.361	0.941
rs12956925	RANK	18	58164620	Intron	0.075	0.083	0.895	0.541–1.481	0.702
rs11877530	RANK	18	58166915	Intron	0.267	0.264	1.014	0.746–1.377	0.938
rs11664594	RANK	18	58169186	Intron	0.495	0.486	1.038	0.792–1.361	0.836
rs12455775*	RANK	18	58170830	Intron	0.261	0.250	1.059	0.776–1.444	0.752
rs6567270	RANK	18	58177985	Intron	0.257	0.267	0.953	0.701–1.296	0.814
rs7239667	RANK	18	58180218	Intron	0.452	0.425	1.118	0.851–1.468	0.445
rs4303637^	RANK	18	58182743	Intron	0.363	0.398	0.862	0.652–1.139	0.319
rs4941131	RANK	18	58191141	Intron	0.313	0.318	0.973	0.727–1.302	0.882
rs6567276	RANK	18	58195648	Intron	0.315	0.297	1.087	0.811–1.458	0.601
rs9646629	RANK	18	58202179	Intron	0.377	0.394	0.933	0.706–1.232	0.671
rs7984870	RANKL	13	42044482	Intron	0.394	0.606	0.560	0.425–0.736	3.07E-5 #
rs9594782	RANKL	13	42049186	intron	0.120	0.116	1.046	0.687–1.590	0.835
rs9566990	RANKL	13	42062710	intron	0.231	0.236	0.972	0.706–1.338	0.871
rs9533166	RANKL	13	42075169	intron	0.192	0.167	1.184	0.832–1.684	0.370
rs2277438	RANKL	13	42053168	intron	0.255	0.222	1.200	0.873–1.650	0.292
rs3102724	OPG	8	120015988	intron	0.380	0.384	0.981	0.742–1.295	0.943
rs1485286	OPG	8	120019849	intron	0.423	0.448	0.903	0.687–1.187	0.487
rs1485288	OPG	8	120019969	intron	0.118	0.097	1.247	0.804–1.934	0.323
rs3134058*	OPG	8	120023289	intron	0.454	0.448	1.024	0.780–1.345	0.890
rs11573856	OPG	8	120024176	intron	0.151	0.163	0.918	0.633–1.332	0.705
rs3102728	OPG	8	120025486	intron	0.125	0.118	1.069	0.706–1.617	0.833
rs3134068	OPG	8	120031840	intron	0.111	0.099	1.131	0.727–1.759	0.652
rs2073618	OPG	8	120033233	missense	0.478	0.361	1.623	1.233–2.141	6.09E-4 #

*Cases = 207, missing = 1

^controls = 211, missing = 1

^# Significant after Bonferroni correction