Table 4. Genotypes and Allele frequencies of rs7984870 of RANKL and rs2073618 of OPG which had potentially statistical significance between cases in AI-related musculoskeletal adverse events group and control.
| Reference SNP ID | Genotype | Frequency no (%) | ||||
|---|---|---|---|---|---|---|
| Cases | Controls | P value | OR | 95%CI | ||
| (n = 208) | (n = 212) | |||||
| rs7984870 | GG | 32(15.4) | 59 (27.8) | 0.002 | 1.0 | |
| CG | 100(48.1) | 110 (51.9) | 0.760 | 1.676 | 1.008–2.787 | |
| CC | 76 (36.5) | 43 (20.3) | 2.19E-4 | 3.259 | 1.843–5.763 | |
| G | 164(39.4) | 228 (53.8) | 3.07E-5 | 1.0 | ||
| C | 252(60.6) | 196(46.2) | 1.787 | 1.359–2.351 | ||
| rs2073618 | GG | 59(28.4) | 83(39.2) | 0.023 | 1.0 | |
| GC | 99(47.6) | 105(49.5) | 0.697 | 1.326 | 0.861–2.043 | |
| CC | 50(24.0) | 24 (11.3) | 7.95 E-4 | 2.931 | 1.624–5.288 | |
| G | 217(52.2) | 271(63.9) | 6.09 E-4 | 1.0 | ||
| C | 199(47.8) | 153 (36.1) | 1.623 | 1.233–2.141 | ||
| rs7984870+ rs2073618 | ||||||
| No risk genotype* | 137 (65.9) | 180 (84.9) | 5.77 E-6 | 1.0 | ||
| With risk genotype | 71 (34.1) | 32 (15.1) | 2.915 | 1.817–4.677 | ||
*rs7984870 haplotype was CC or rs2073618 haplotype was CC