Table 5. Differences of estradiol, CTX, PINP and BMD with risk genotype or no risk genotype in AI-related musculoskeletal adverse events group.
| Genotype | Genotype | P value | |
|---|---|---|---|
| Risk | No risk | ||
| rs7984870 CC | rs7984870 GG | ||
| (n = 76) | (n = 32) | ||
| E2 (pg/ml) | 8.72 ± 4.96 | 9.11 ± 5.02 | 0.409 |
| CTX (pg/ml) | 242.1 ± 98.1 | 229.7 ± 86.8 | 1.11E-6 |
| PINP (pg/ml) | 371.6± 139.9 | 336.3 ± 123.1 | 1.50E-7 |
| Lumbar spine BMD (g/cm2) | 0.806 ± 0.186 | 0.975 ± 0.206 | 0.075 |
| WHO-criteria | n (%) | n (%) | |
| Lumbar spine BMD T-score | |||
| <−2.5 SD (Osteoporosis) | 23(30.2) | 3(9.4) | 0.026 |
| −2.5 SD–−1.0 SD (Osteopenia) | 32(42.1) | 6(18.8) | 0.027 |
| −>1.0 SD (Normal) | 21(27.2) | 23(71.8) | 3.15E -5 |
| rs2073618 CC | rs2073618 GG | ||
| (n = 50) | (n = 59) | ||
| E2 (pg/ml) | 8.59 ± 5.06 | 9.19 ± 5.77 | 0.181 |
| CTX (pg/ml) | 252.6 ± 99.5 | 223.9 ±84.3 | 3.68E-9 |
| PINP (pg/ml) | 369.1± 127.4 | 325.0 ± 120.2 | 5.09E-10 |
| Lumbar spine BMD (g/cm2) | 0.801 ± 0.218 | 0.987 ± 0.257 | 0.049 |
| WHO-criteria | n (%) | n (%) | |
| Lumbar spine BMD T-score | |||
| <−2.5 SD (Osteoporosis) | 18(36.0) | 10(16.9) | 0.029 |
| −2.5 SD–−1.0 SD (Osteopenia) | 20(40.0) | 12(20.3) | 0.034 |
| −>1.0 SD (Normal) | 12(24.0) | 37(62.7) | 9.20E-5 |
Note: E2 = estradiol; BMD = bone mineral density.