Figure 1.

Identification of co-occurrence and mutual exclusivity interactions in different types of cancer

1. Randomization procedure to identify interactions across 22 cancer types.
2. Numbers of interactions, their interaction types (left), and their alteration types (right) identified in analyses of 14 different cancer types in which interactions were detected (FDR = 0.1). The remaining 8 of 22 cancer types had no detected interactions. See FigureEV1 for the same analysis at a stricter FDR (FDR = 0.05).
3. Overlap between the interactions detected in the pan-cancer analysis and in the analyses of individual cancer types. Of the 39 interactions only detected in the analyses of individual cancer types, 10 were also tested in the pan-cancer analysis. All of the 34 interactions only detected in the pan-cancer analysis were also tested in at least one individual cancer type.
4. Most interactions were only detected in a single type of cancer.