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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Vascul Pharmacol. 2015 May 23;72:163–171. doi: 10.1016/j.vph.2015.05.007

Figure 1. MnTBAP modulates pro-angiogenic signaling pathways.

Figure 1

MnTBAP activates Akt and eNOS in a concentration- (A) and time-dependent manner (B). Pre-treatment with wortmannin inhibits MnTBAP induced phosphorylation of Akt and eNOS (C). Stimulation with increasing concentration of NAC does not result in activation of Akt or eNOS (D). Treatment of HUVECs with NAC for different time also shows no significant activation of Akt or eNOS (E). Data are presented as mean±SEM and are representative of at least 3 independent experiments. *P ≤ 0.05.