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. 2015 Aug 20;2(5):e148. doi: 10.1212/NXI.0000000000000148

Figure 2. IVIg therapy partially restores FcγR expression on B cells and monocytes.

Figure 2

Flow cytometry analysis of Fc-gamma receptor (FcγR) expression on peripheral blood mononuclear cells of treatment-naïve patients with chronic inflammatory demyelinating polyneuropathy (CIDP) as well as 2 and 4–8 weeks after a single dose of IV immunoglobulin (IVIg) (2 g/kg) treatment. Data points for individual patients are connected by lines. Three patients did not show improvement on the modified Rankin Scale 4 weeks after the first course of IVIg therapy (red lines) but improved after a second course of IVIg and thereafter received long-term maintenance therapy. For some patients not all data points were available. Changes of FcγRIIB (A) as well as FcγRI (B) and FcγRIIA (C) median fluorescence intensity following IVIg treatment are shown relative to baseline (untreated). Statistics were performed using the Wilcoxon signed rank test.