Table 1.
Compositions and functions of ER–endosome contact sites
| Contact site | Function | References | |
|---|---|---|---|
| ER | Endosome | ||
| PTP1B | EGFR | Receptor dephosphorylation in-trans | Eden et al (2010) |
| PTP1B | G-CSFR | Receptor dephosphorylation in-trans | Palande et al (2011) |
| VAP-A | STARD3/MLN64 | Endosome positioning? | Alpy et al (2013); van der Kant et al (2013b) |
| VAP-A | STARD3NL/MENTHO | Control of endosome tubulation? | Alpy et al (2013) |
| VAP-A | ORP1L | Negative regulation of dynein association with LEs (when cholesterol concentration is low) | Rocha et al (2009) |
| ORP5 | NPC1 | Cholesterol transport between LEs and ER? | Du et al (2011); Du & Yang (2013) |
| Protrudin (+VAP-A) | Rab7-GTP + PtdIns3P | LE translocation to cell periphery mediated by transfer of kinesin-1 from ER to LEs | Raiborg et al (2015) |
| ? | FAM21 ? | Definition of sites for endosome fission | Rowland et al (2014) |
The moieties associated with ER and endosome membranes are indicated.