Fig. 4.
Genome linkage analysis for early-onset hearing loss in D2J mice. (A) Genome-wide interval mapping for susceptibility genes associated with early-onset hearing loss for 8- (solid curve) and 16-kHz (dotted curve) stimuli of the (BDF1 × D2J) N2 mice. Chromosome numbers and marker positions (vertical bars) are given below the linkage map. The horizontal lines indicate significant LOD thresholds at 8 (solid, LOD = 2.69) and 16 (dotted, LOD = 2.71) kHz, respectively. (B) Magnified view of the significant QTLs at chromosome 5.