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Mean (± SE) heart rate (beats/min) in Sprague Dawley rats (n=6/age group: 3, 6, and 12 months old) following intraperitoneal administration of 125 mg/kg of ketamine and 10 mg/kg xylazine. The heart rate was evaluated with a pulse oximeter at selected time points (5, 15, 30, and 45 min, and 1, 1.5, and 2 h), with the evaluations ending when animals had a positive withdrawal reflex. *P<0.01.
