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. 2015 Aug 24;212(9):1433–1448. doi: 10.1084/jem.20141555

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© 2015 Qian et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — FLT1 tyrosine kinase domain is critical for human breast tumor cell metastasis. (a–d) Experimental metastasis of 4173 cells in Rag2^−/− littermate heterozygous or homozygous for Flt1^tk targeted mutation with stereological quantification. (e–h) Distal metastasis efficiency of 4173 cells in bone marrow mosaic nude mice with littermate donor of Rag2^−/−; Flt1^tk/+ or Rag2^−/−; Flt1^tk/tk mice with stereological quantification. Metastasis quantification was the same as in Fig. 1. Data show mean + SEM. n ≥ 5; *, P < 0.05; **, P < 0.01 by Student’s t test.