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. 2015 Aug 24;212(9):1433–1448. doi: 10.1084/jem.20141555

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© 2015 Qian et al.

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Figure 8. — FLT1-regulated CSF1 expression through p-FAK1. (a) Efficacy of FLT1 blockade using MF1 antibody against a panel of 45 proteins and phosphor-proteins on a reverse protein array. Color bar shows relative expression value (global normalization, refer to Table S1 for epitope information). Phosphorylation of p38 and FAK1 show the most notable reduction upon FLT1 blockade using MF1 antibody. n = 2. (b) Western blot showing inhibition of phosphor-p38 and phosphor-FAK1 in BMMs from littermate mice heterozygous or homozygous for Flt1^tk. Representative blot from two independent experiments. (c) FAK1 inhibitor blocks tumor cell–conditioned medium (CM)–induced mRNA Csf1 expression in BMMs. Data show mean + SEM. n = 3; *, P < 0.05 by ANOVA plus Dunnett’s multiple comparison test.